Could maternal serum MFG-E8 level predict adverse first trimester pregnancy outcome? A preliminary study

Background/aim: Milk fat globule-epidermal growth factor 8 (MFG-E8) is expressed in the endometrial epithelium and its expression increases during implantation process. Due to this knowledge, we aimed investigate maternal serum MFG-E8 levels on both healthy pregnant women first trimester complicated with missed abortion threatened trimester. Materials methods: This prospective, cross-sectional study was conducted a tertiary referral hospital, department of obstetrics between July 2020 February 2021 after ethical committee approval. The population consisted 30 (HP) trimester, suffering from (TA) (MA) Maternal were analyzed enzyme linked immunosorbent assay. Delivery neonatal outcomes evaluated. continuous variables compared among three groups variance analysis post hoc tests. categorical chi-square Fisher's exact tests where applicable. Results: mean age 29.36 ± 5.31 years. There no significant difference for parameters age, body mass index, parity number, gestational week. Despite being within normal ranges, neutrophil international normalized ratio values showed statistically (p < 0.05). MA, TA, HP 270 152.3, 414.7 236.7, 474 222.5 ng/mL, respectively = 0.001). It found that MA group significantly lower than those other two Conclusion: Although level seems be parameter differ live nonlive pregnancies, studies large number cases are needed discuss our results determine cut-off value prediction